Opportunity Information: Apply for CDC RFA CK 25 0144
The Centers for Disease Control and Prevention (CDC), through NCEZID, is offering a discretionary cooperative agreement under funding opportunity CDC RFA CK 25 0144 titled "Creutzfeldt-Jakob Disease (CJD) Increasing Educational Support for CJD Families and the Nation." The focus of the opportunity is educational support and timely information-sharing related to human prion diseases, especially Creutzfeldt-Jakob disease, which is described as a rare but devastating and incurable brain disorder occurring at roughly one case per million people per year. Because most patients die within about six months of symptom onset and often become fully dependent on caregivers for basic daily needs, the grant frames education and support for families and caregivers as an urgent public health need.
A central motivation for the program is strengthening awareness and preparedness around variant CJD, a form that emerged in the United Kingdom in 1996 and was linked to bovine spongiform encephalopathy (BSE). The NOFO notes that more than 230 variant CJD cases have been identified worldwide and that four cases have occurred in the United States, with exposure believed (based on epidemiologic evidence) to have happened outside the country. The CDC is emphasizing that better, faster distribution of accurate information can support prevention where possible, improve monitoring and understanding of prion diseases, and help reduce the incidence of preventable forms such as variant CJD.
The opportunity also highlights the need to stay ahead of potentially emerging prion threats, including the possibility of new prion diseases in humans, such as a potential human form related to chronic wasting disease (CWD). CWD is an ongoing prion disease outbreak affecting deer and elk in the United States and continues to spread. Within that context, the grant’s education mission extends beyond families to include public health service providers, other health professionals, and groups considered at higher risk, with the broader goal of improving surveillance readiness and early identification of concerning trends.
In practical terms, this is a cooperative agreement (not a simple pass-through grant), meaning recipients should expect substantial involvement or collaboration with CDC in carrying out the work. The NOFO anticipates making a single award (expected awards: 1), with an award ceiling of $100,000. Applications requesting more than $100,000 will be treated as non-responsive and will not move forward for review, making budget alignment a strict requirement.
Eligibility is broad and includes state and local governments (states, counties, cities/townships, special districts), public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories), as well as for-profit organizations (including small businesses). The closing date listed for applications is March 18, 2025, and the CFDA/Assistance Listing associated with the program is 93.317.Apply for CDC RFA CK 25 0144
- The Centers for Disease Control - NCEZID in the health sector is offering a public funding opportunity titled "Creutzfeldt-Jakob Disease (CJD) Increasing Educational Support for CJD Families and the Nation" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.317.
- This funding opportunity was created on 2025-01-17.
- Applicants must submit their applications by 2025-03-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Unrestricted.
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Frequently Asked Questions (FAQs)
What is the name of this CDC funding opportunity?
The funding opportunity is titled "Creutzfeldt-Jakob Disease (CJD) Increasing Educational Support for CJD Families and the Nation" and is listed as CDC RFA CK 25 0144.
Which CDC center is offering this opportunity?
The opportunity is offered by the Centers for Disease Control and Prevention (CDC) through NCEZID.
What type of funding mechanism is this?
This is a discretionary cooperative agreement, not a simple pass-through grant.
What does it mean that this is a cooperative agreement?
It means the recipient should expect substantial involvement or collaboration with CDC while carrying out the funded work.
What is the main focus of the project?
The central focus is educational support and timely information-sharing related to human prion diseases, especially Creutzfeldt-Jakob disease (CJD), with an emphasis on supporting families and caregivers and improving broader awareness and preparedness.
Why is education and support for CJD families and caregivers considered urgent?
The opportunity describes CJD as a rare but devastating and incurable brain disorder. It notes that most patients die within about six months of symptom onset and often become fully dependent on caregivers for basic daily needs, creating an urgent need for education and support.
How common is Creutzfeldt-Jakob disease (CJD)?
The NOFO describes CJD as occurring at roughly one case per million people per year.
What kinds of diseases are included under the term "human prion diseases" in this opportunity?
The opportunity centers on human prion diseases, especially CJD, and also discusses variant CJD as a key preparedness concern. It further highlights the possibility of potentially emerging prion threats (including a potential human form related to chronic wasting disease).
What is variant CJD, and why is it emphasized in this opportunity?
Variant CJD is a form that emerged in the United Kingdom in 1996 and was linked to bovine spongiform encephalopathy (BSE). The opportunity emphasizes strengthening awareness and preparedness around variant CJD and improving the speed and accuracy of information distribution.
How many variant CJD cases have been identified worldwide?
The NOFO notes that more than 230 variant CJD cases have been identified worldwide.
How many variant CJD cases have occurred in the United States?
The opportunity states that four cases have occurred in the United States.
Does the opportunity indicate where U.S. variant CJD exposures likely occurred?
Yes. It notes that, based on epidemiologic evidence, exposure for the U.S. cases is believed to have happened outside the country.
What public health outcomes is the CDC aiming to support through this education-focused award?
The opportunity explains that better, faster distribution of accurate information can help support prevention where possible, improve monitoring and understanding of prion diseases, and help reduce the incidence of preventable forms such as variant CJD.
Does the opportunity address emerging or future prion threats beyond CJD?
Yes. It highlights the need to stay ahead of potentially emerging prion threats, including the possibility of new prion diseases in humans, such as a potential human form related to chronic wasting disease (CWD).
What is chronic wasting disease (CWD) as described in the opportunity?
CWD is described as an ongoing prion disease outbreak affecting deer and elk in the United States that continues to spread.
Who is the education mission intended to reach?
The opportunity frames education and support as extending beyond families to include public health service providers, other health professionals, and groups considered at higher risk, with a broader goal of improving surveillance readiness and early identification of concerning trends.
How many awards does the NOFO expect to make?
The NOFO anticipates making a single award (expected awards: 1).
What is the maximum award amount (ceiling) for this opportunity?
The award ceiling is $100,000.
What happens if an application requests more than $100,000?
Applications requesting more than $100,000 will be treated as non-responsive and will not move forward for review, so aligning the budget to the ceiling is a strict requirement.
Who is eligible to apply?
Eligibility is broad and includes:
- State and local governments (states, counties, cities/townships, special districts)
- Public and private institutions of higher education
- Federally recognized tribal governments and other tribal organizations
- Public housing authorities and Indian housing authorities
- Nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories)
- For-profit organizations (including small businesses)
Is a 501(c)(3) designation required to apply?
No. The opportunity states that nonprofit organizations with or without 501(c)(3) status are eligible (with the noted exception that higher education institutions are listed separately under institutions of higher education).
Are for-profit organizations eligible to apply?
Yes. The eligibility list includes for-profit organizations, including small businesses.
Are tribal entities eligible to apply?
Yes. Eligibility includes federally recognized tribal governments and other tribal organizations.
Are state and local government entities eligible to apply?
Yes. Eligibility includes state and local governments such as states, counties, cities/townships, and special districts.
What is the application due date?
The closing date listed for applications is March 18, 2025.
What is the CFDA/Assistance Listing number for this opportunity?
The CFDA/Assistance Listing associated with this program is 93.317.
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