Opportunity Information: Apply for HT9425 23 CPMRP PMCCRA
The DOD Chronic Pain Management, Pain Management Collaborative Clinical Research Award (FY23 CPMRP PMCCRA) is a Department of Defense funding opportunity focused on improving how chronic pain is managed in real-world care settings, especially those serving Service Members, Veterans, and their families. The program is built around supporting large-scale, pragmatic clinical trials that compare existing, evidence-based pain management options and study how best to implement them in routine practice. The overall goal is to speed up acceptance and consistent use of proven chronic pain management approaches across the Military Health System (MHS), the Department of Veterans Affairs (VA), and other health care organizations that treat these populations.
A key expectation is that proposed projects are not just testing whether an approach works, but also generating practical evidence that can shape clinical standards of care. Applications are expected to clearly explain how the results will inform the development, refinement, or revision of existing recommendations, guidelines, or models of care for chronic pain. Because the intent is to influence practice at scale, the emphasis is on comparative effectiveness research (how well different established options perform in real-world conditions) and implementation science (how to integrate and sustain those options in health systems). Strong collaboration with VA and/or MHS providers is described as essential, since partnering with these delivery systems is central to producing results that are meaningful and actionable in the environments where military and Veteran patients actually receive care.
The award is specifically tied to congressional appropriations for chronic pain research, so every application must have chronic pain as the primary focus, either on its own or alongside common comorbidities. Projects that mainly center on other conditions such as traumatic brain injury, depression, or PTSD (even when pain is present) are considered out of scope for this mechanism. Likewise, the program is not intended to support development of new opioid-based therapies, and applications proposing novel opioid interventions will not be selected. That said, studies that aim to understand, optimize, or reduce opioid use within current prescribing practices, as part of chronic pain management, are allowed as long as the core focus remains chronic pain care and outcomes.
Funding under this mechanism must support a clinical trial. In practical terms, the program is requiring prospective assignment of human participants to one or more interventions (which can include a control or placebo when appropriate) in order to evaluate biomedical or behavioral health-related outcomes, including outcomes related to safety, effectiveness, and/or efficacy. Projects that do not measure an intervention outcome of that kind would not meet the definition of a clinical trial for this announcement. Importantly, the interventions studied are expected to be approaches that have already shown efficacy in some settings; the PMCCRA is not the right fit for first-in-kind, experimental, or untested pharmacologic or non-pharmacologic therapies. Applicants wanting to test novel treatments are directed instead toward the FY23 Clinical Exploration Award.
Structurally, the PMCCRA is designed as a phased program. It begins with a 15-month planning phase meant to complete the concrete steps needed to launch a complex, multi-site pragmatic trial. Examples include securing regulatory approvals, finalizing data collection tools and common data elements, and onboarding and activating study sites. After that planning period, a second phase to execute the full-scale clinical trial is described as optional and would be considered as a separate next step rather than guaranteed upfront. The mechanism is offered by the Department of Defense (Department of the Army, USAMRAA) under Funding Opportunity Number HT9425 23 CPMRP PMCCRA (CFDA 12.420), uses grant and/or cooperative agreement instruments, is open to a broad range of applicant organizations (with any limits only as clarified in the full announcement), and was anticipated to make a very limited number of awards (listed as 1 for this cycle).Apply for HT9425 23 CPMRP PMCCRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Chronic Pain Management, Pain Management Collaborative Clinical Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jul 03, 2023.
- Applicants must submit their applications by Nov 09, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DOD Chronic Pain Management, Pain Management Collaborative Clinical Research Award (FY23 CPMRP PMCCRA)
What is the FY23 CPMRP PMCCRA funding opportunity?
The Chronic Pain Management, Pain Management Collaborative Clinical Research Award (FY23 CPMRP PMCCRA) is a Department of Defense (DOD) funding opportunity focused on improving chronic pain management in real-world care settings, especially those serving Service Members, Veterans, and their families.
What is the main purpose of this award?
The purpose is to support large-scale, pragmatic clinical trials that compare existing, evidence-based pain management options and evaluate how best to implement them in routine practice. The broader goal is to speed up acceptance and consistent use of proven chronic pain management approaches across the Military Health System (MHS), the Department of Veterans Affairs (VA), and other health care organizations serving these populations.
What types of research are emphasized by this program?
The program emphasizes comparative effectiveness research (how well different established options perform in real-world conditions) and implementation science (how to integrate and sustain those options in health systems) so results can influence practice at scale.
Does the project need to influence clinical practice or standards of care?
Yes. Applications are expected to explain how findings will inform the development, refinement, or revision of existing recommendations, guidelines, or models of care for chronic pain, with an intent to shape clinical standards of care.
Is collaboration with VA and/or MHS required or expected?
Strong collaboration with VA and/or MHS providers is described as essential because partnering with these delivery systems is central to producing results that are meaningful and actionable in the settings where military and Veteran patients receive care.
What population and care settings are most relevant to the PMCCRA?
Projects should be relevant to real-world care settings that serve Service Members, Veterans, and their families, with the goal of impact across the MHS, the VA, and other health care organizations that treat these populations.
Must chronic pain be the primary focus of the application?
Yes. Because the award is tied to congressional appropriations for chronic pain research, every application must have chronic pain as the primary focus, either alone or alongside common comorbidities.
Are projects focused mainly on other conditions allowed if pain is involved?
No. Projects that mainly center on other conditions (such as traumatic brain injury, depression, or PTSD), even when pain is present, are considered out of scope for this mechanism.
Are opioid-related studies allowed?
Novel opioid-based therapy development is not supported, and applications proposing novel opioid interventions will not be selected. However, studies that aim to understand, optimize, or reduce opioid use within current prescribing practices can be allowed, as long as the core focus remains chronic pain care and outcomes.
Is a clinical trial required under this award?
Yes. Funding under this mechanism must support a clinical trial.
How does this announcement define a clinical trial?
It requires prospective assignment of human participants to one or more interventions (which may include a control or placebo when appropriate) to evaluate biomedical or behavioral health-related outcomes, including outcomes related to safety, effectiveness, and/or efficacy.
Can a project be funded if it does not measure intervention outcomes?
No. Projects that do not measure an intervention outcome of the required type would not meet the definition of a clinical trial for this announcement.
What kinds of interventions should be studied?
The interventions are expected to be approaches that have already shown efficacy in some settings. The program is intended to compare and implement established, evidence-based pain management options rather than test first-in-kind or unproven therapies.
Can applicants propose experimental or first-in-kind therapies?
No. The PMCCRA is not the right fit for first-in-kind, experimental, or untested pharmacologic or non-pharmacologic therapies.
Where should applicants look if they want to test novel treatments?
Applicants who want to test novel treatments are directed to the FY23 Clinical Exploration Award rather than this mechanism.
What is meant by "pragmatic" clinical trials in this program?
The program is built around pragmatic trials in real-world care settings, meaning the research is designed to generate practical evidence about how established pain management options perform and can be implemented under routine conditions.
Is the PMCCRA structured in phases?
Yes. The mechanism is designed as a phased program that begins with a planning phase and may be followed by an optional execution phase for the full-scale clinical trial.
How long is the planning phase and what is it for?
The planning phase is 15 months and is intended to complete the concrete steps needed to launch a complex, multi-site pragmatic trial.
What are examples of activities supported during the planning phase?
Examples include securing regulatory approvals, finalizing data collection tools and common data elements, and onboarding and activating study sites.
Is the second phase (full-scale trial execution) guaranteed?
No. The second phase to execute the full-scale clinical trial is described as optional and would be considered as a separate next step rather than guaranteed upfront.
Who is offering this funding opportunity?
This mechanism is offered by the Department of Defense, Department of the Army, USAMRAA.
What is the Funding Opportunity Number and CFDA listing for this program?
The Funding Opportunity Number is HT9425 23 CPMRP PMCCRA, and the CFDA listing is 12.420.
What funding instruments may be used for awards?
The opportunity uses grant and/or cooperative agreement instruments.
Who is eligible to apply?
The opportunity is described as open to a broad range of applicant organizations, with any limits only as clarified in the full announcement.
How many awards were anticipated for this cycle?
A very limited number of awards was anticipated for this cycle, listed as 1.
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