Genetics of Alcohol Sensitivity and Tolerance (R01 Clinical Trial Not Allowed) | PA 18 660

Opportunity Information: Apply for PA 18 660

The Genetics of Alcohol Sensitivity and Tolerance (R01 Clinical Trial Not Allowed) funding opportunity (PA 18-660) is a National Institutes of Health (NIH) research grant program in the health category (CFDA 93.273) focused on advancing the science of why people differ in their responses to alcohol and how those differences contribute to alcohol use disorder risk. The central aim is to encourage research that connects human studies with animal model studies in a more coordinated way, so investigators can generate new, testable hypotheses and establish shared experimental frameworks. In practice, this means supporting projects that can bridge findings across species and methods to clarify how genetic variation, genomic mechanisms, and epigenetic regulation shape alcohol sensitivity, the development of tolerance over time, and the biological pathways that may drive progression toward alcohol dependence.

A key emphasis of the opportunity is on understanding underlying biology rather than conducting clinical trials, as indicated by the “Clinical Trial Not Allowed” designation. Proposed work should therefore be designed as non-clinical-trial research, such as mechanistic studies, integrative analyses, model development, or translational research that links human observational or laboratory-based phenotyping to parallel experimentation in animals. The intent is to build stronger cross-cutting approaches where measurements and concepts align between human and animal research, enabling clearer interpretation of results and more reliable translation of discoveries into a better understanding of alcohol dependence vulnerability.

The award mechanism is the NIH R01, which typically supports substantial, investigator-driven research projects. The funding instrument type is a grant, and the opportunity is listed as discretionary. While the source data provided does not specify an award ceiling or the expected number of awards, the R01 format generally indicates support for well-developed projects with a defined set of aims, methods, and outcomes that can meaningfully advance knowledge in the field of alcohol sensitivity and tolerance genetics.

Eligibility is broad and includes many types of domestic applicants: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The announcement also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal government agencies; regional organizations; U.S. territories or possessions; and non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility reflects a goal of drawing on diverse scientific perspectives, populations, and institutional capacities to address complex genetic and biological questions about alcohol response and dependence risk.

Administrative details in the provided data indicate the opportunity was created on 2018-02-14, with an original closing date listed as 2021-05-07. Applicants interested in this area would typically look to NIH’s current notices or reissued announcements for the most up-to-date submission dates and policies, but the core scientific focus remains clear: build integrated, cross-species research strategies to explain how genetic, genomic, and epigenetic factors influence alcohol sensitivity and tolerance, and how these mechanisms contribute to the trajectory toward alcohol dependence.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Genetics of Alcohol Sensitivity and Tolerance (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
• This funding opportunity was created on 2018-02-14.
• Applicants must submit their applications by 2021-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 660

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