NIA Multi-site Clinical Trial Implementation Grant (R01 Clinical Trial Required) | PAR 23 057

Opportunity Information: Apply for PAR 23 057

The NIA Multi-site Clinical Trial Implementation Grant (R01 Clinical Trial Required), Funding Opportunity Number PAR-23-057, is a National Institutes of Health discretionary grant opportunity that supports the actual conduct and execution of investigator-initiated, multi-site interventional clinical trials. It is designed for trials in any phase, as long as the work is interventional, hypothesis-driven, and clearly structured around defined milestones that allow progress to be tracked and managed across participating sites. The scientific focus of the proposed trial must align with the National Institute on Aging (NIA) research mission, meaning applicants should ensure their clinical question, target population, outcomes, and overall rationale are tightly connected to aging-related research priorities described by NIA.

This FOA is specifically aimed at the implementation stage of a multi-site study, which typically means the application should be ready to move into trial operations rather than early concept development. In practical terms, that generally implies applicants are expected to present a well-justified research plan, a realistic and well-governed multi-site structure, and an operational approach that addresses core clinical trial requirements such as recruitment and retention strategies, protocol adherence across sites, data collection and management, safety monitoring, and performance benchmarks. The emphasis on being milestone-defined signals that the funding agency expects applicants to lay out measurable deliverables (for example, site activation timelines, enrollment targets, follow-up completion rates, and data quality metrics) and to manage the project using those checkpoints.

Eligibility is broad and includes many types of U.S.-based organizations as well as certain non-U.S. entities. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits both with and without 501(c)(3) status (excluding institutions of higher education when relevant); for-profit organizations other than small businesses; small businesses; and other organizations that meet NIH eligibility rules. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities/foreign organizations, indicating a strong openness to a wide range of institutional settings and community-connected research infrastructure.

Administratively, the opportunity is offered by the National Institutes of Health under the Health funding activity category and is associated with CFDA number 93.866. The funding instrument is a grant, and the title specifies that it is an R01 mechanism with a clinical trial required component, meaning the application must propose a clinical trial that meets NIH’s definition and the project will be reviewed and managed accordingly. The original closing date listed is January 7, 2026. The provided source information does not specify an award ceiling or the expected number of awards, so applicants would typically need to consult the full FOA text and NIH guidance for any budget-related expectations, allowable costs, and submission details.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIA Multi-site Clinical Trial Implementation Grant (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2022-11-30.
• Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 23 057

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: