Opportunity Information: Apply for PAR 21 181
The NINDS Program Project Grant (P01 Clinical Trial Optional), funding opportunity number PAR-21-181, is a National Institutes of Health grant program run by the National Institute of Neurological Disorders and Stroke (NINDS). It is meant to support large, coordinated research efforts in neurology and neuroscience that tackle major scientific questions aligned with the NINDS mission. The central idea is to fund a set of closely connected research projects that are intentionally designed to work together, so that the overall scientific payoff is greater than what would be achieved if each project were funded separately as stand-alone awards. This FOA emphasizes interactive, innovative research built around synergy: investigators are expected to collaborate in ways that create added value, such as shared hypotheses, integrated aims, complementary methods, cross-project data or resource sharing, and a unified scientific vision that would be difficult to execute through independent grants.
A key feature of the P01 mechanism is that it supports several interdependent, highly meritorious projects under one umbrella program. Applications are expected to demonstrate why the grouped structure is necessary, what scientific advantages come from the integration, and how the different projects strengthen one another. NINDS is specifically looking for programs that bring together outstanding scientists, including teams that might not otherwise collaborate, to address significant problems in neurological disorders, stroke, and related areas. The “clinical trial optional” designation means the program may include clinical trial work if it is appropriate to the proposed science, but clinical trials are not required; applicants can propose either non-trial research or research that includes trials, depending on the goals of the program.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants listed in the opportunity include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in those specific nonprofit categories); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), regional organizations, eligible agencies of the federal government, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
At the same time, there are important geographic and organizational restrictions. Non-domestic (non-U.S.) entities, meaning foreign institutions, are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, “foreign components” are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S. applicant can include certain well-justified international elements or collaborations within the project structure when permitted under NIH rules, even though the primary applicant must be U.S.-based.
This opportunity is categorized as a discretionary grant within the health funding activity category, associated with CFDA number 93.853. The FOA was created on April 5, 2021, and the original closing date listed is May 7, 2024. While the provided source data does not specify an award ceiling or expected number of awards, the intent is clear: NINDS is using the P01 mechanism to invest in integrated, multi-project research programs where the collaborative design is essential to achieving the scientific aims, and where the combined effort can advance understanding, prevention, diagnosis, and treatment related to neurological disorders and stroke more effectively than separate, individual grants.Apply for PAR 21 181
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Program Project Grant (P01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on 2021-04-05.
- Applicants must submit their applications by 2024-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NINDS Program Project Grant (P01 Clinical Trial Optional) - PAR-21-181
What is this grant opportunity?
This opportunity is the NINDS Program Project Grant (P01 Clinical Trial Optional), funding opportunity number PAR-21-181. It is a National Institutes of Health (NIH) grant program administered by the National Institute of Neurological Disorders and Stroke (NINDS).
What is the purpose of the NINDS P01 mechanism?
The P01 mechanism is intended to support large, coordinated research efforts in neurology and neuroscience that tackle major scientific questions aligned with the NINDS mission. It funds a set of closely connected projects designed to work together so the overall impact is greater than what would be achieved if each project were funded separately.
What kind of research does NINDS want under this FOA?
NINDS is looking for interactive, innovative research programs built around synergy across multiple projects. Applications should reflect a unified scientific vision and demonstrate that integration across projects is essential to achieving the program goals.
What does "synergy" mean in the context of this P01 FOA?
Synergy refers to collaboration and integration that create added scientific value beyond separate stand-alone projects. Examples described in the opportunity include shared hypotheses, integrated aims, complementary methods, cross-project data or resource sharing, and coordinated efforts that would be difficult to execute through independent grants.
How is a P01 different from submitting several independent grants?
A P01 application is expected to justify why a grouped, multi-project structure is necessary and what advantages come from integration. The goal is to show that the projects are interdependent and strengthen one another, producing a combined payoff greater than separate awards would provide.
Does the program have to include a clinical trial?
No. The FOA is designated "clinical trial optional," meaning clinical trial work may be included if it fits the proposed science, but a clinical trial is not required.
Can applicants propose a program that includes clinical trials?
Yes. Because the FOA is "clinical trial optional," applicants may propose research that includes clinical trials when appropriate to the program's scientific goals.
What does "clinical trial optional" imply for project design?
It means the proposed program can be entirely non-trial research or can include clinical trial components. The choice should be driven by what best supports the overall integrated scientific aims of the multi-project program.
Who can apply?
Eligibility is broad and includes many U.S.-based organizations and governmental entities. Eligible applicants listed include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (in the specified categories); for-profit organizations other than small businesses; small businesses; and other eligible entities.
Are minority-serving institutions and similar organizations eligible?
Yes. The FOA explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); regional organizations; eligible agencies of the federal government; Indian/Native American tribal governments other than federally recognized; and U.S. territories or possessions.
Can a foreign (non-U.S.) organization apply as the applicant?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization under this opportunity.
Can a non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization.
Are international collaborations allowed at all?
Yes, in a limited way. While the primary applicant must be U.S.-based, "foreign components" are allowed as defined in the NIH Grants Policy Statement. This generally means a U.S. applicant may include certain well-justified international elements or collaborations within the project structure when permitted under NIH rules.
What scientific areas does this opportunity target?
The FOA is focused on neurology and neuroscience and is aimed at significant problems in neurological disorders, stroke, and related areas, consistent with the NINDS mission.
What is the key expectation for how investigators work together?
NINDS expects investigators to collaborate in ways that create added value across projects, including integrated aims and methods, shared hypotheses, and cross-project sharing of data or resources, all guided by a unified scientific vision.
Does this FOA encourage new or unusual team structures?
Yes. The FOA specifically notes interest in programs that bring together outstanding scientists, including teams that might not otherwise collaborate, to address significant scientific problems.
What grant type and funding category is this opportunity associated with?
This opportunity is categorized as a discretionary grant within the health funding activity category and is associated with CFDA number 93.853.
What is the funding opportunity number?
The funding opportunity number is PAR-21-181.
When was this FOA created?
The FOA was created on April 5, 2021.
What is the closing date listed in the provided information?
The original closing date listed is May 7, 2024.
Does the provided information state an award ceiling or the expected number of awards?
No. The provided source data does not specify an award ceiling or the expected number of awards.
What does the FOA suggest about the scale and structure of the funded work?
It emphasizes integrated, multi-project research programs where multiple interdependent, highly meritorious projects are supported under one umbrella program, and where collaborative design is essential to achieving the scientific aims.
What kind of justification should an application provide for being a P01?
Applications are expected to demonstrate why the grouped structure is necessary, what scientific advantages come from integration, and how the different projects strengthen one another to produce a greater overall payoff than stand-alone projects would.
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